Geneious Biologics has exciting features to announce for the New Year! In this article we will cover the main highlights from the last few months:
- Protein Statistics calculated for whole molecules - mAb and fAb
- NGS, Barcode and UMI functionality for Peptide Annotator
- Updated Human and Mouse Ig Reference databases
- Streamlined Graph Selection
Protein Statistics for whole molecules - mAb and fAb
We now support calculating protein properties like the isoelectric point, extinction coefficient, etc. for a protein complex - a mAb or fAb. This requires that you have paired IgG heavy-light chains with a fully sequenced variable region plus a portion of the constant region.
Note: The new mAb and fAb options are only supported for our new 2025 Reference Databases
The setting is available for all our antibody annotation pipelines (E.g. the Antibody Annotator) and can be selected under the Analysis Options:
To learn more about the details of this option and the properties calculated, see our main article: Protein Statistics.
NGS, Barcode and UMI functionality for Peptide Annotator
The Peptide Annotator now has a Collapsing and Filtering section which allows you to reduce your dataset down to unique sequences. Non-antibody sequences can now be collapsed (while retaining the counts) according to sequence identity. Barcoded and UMI datasets are also now supported.
Note: The collapse settings will be used by default if there are more than 10,000 input sequences.
To learn more about the collapse settings, see our main article on the Peptide Annotator.
Human and Mouse Ig 2025 Reference Databases
We now have two updated reference databases for both Human and Mouse Ig genes. These include the full heavy constant gene (including CH1, hinge, CH2 and CH3 regions) which enable the calculations of protein properties for full IgG antibodies.
These are fully up-to-date with the germline genes deposited at NCBI. Please reach out to us if you would like any more information on these databases.
Streamlined Graph Selection
We have updated the panel for graph selections to make these much more tidy. This will make navigating to and setting up graphs with more complex settings much easier, like Alignment trees and Network graphs.
We will also be adding the Cluster Network and Cluster Tree graphs to the top-line graphs tab, rather than just below your sequences table.